Under the hood of ALPHABULK by Olympus Labs
Read time: 10 min
ALPHABULK is a novel nutraceutical masterpiece! We know this is an extreme claim, but anyone who has tried Olympus Labs' unique products can confidently attest that when Olympus Labs says something, they truly deliver!
OL is confident that they have created something special, something so unique and powerful that in true Olympus Labs style, it delivers unrivalled potent lean mass gains and simultaneous fat loss compared to anything available on the market.
ALPHABULK features an industry-first powerhouse anabolic agent α-Cedrene, dosed at a clinically efficacious level. It has been shown to potently enhance skeletal muscle mass and strength while enhancing fat loss! Working in unison with α-Cedrene is another superstar addition that made its introduction in K1NGS PCT, α-Ionone but this time in its most potent liquid form, to deliver a full clinically validated dosage to drive muscle protein synthesis to the extreme further, while simultaneously being a powerful anti-catabolic and lipotropic agent. ALPHABULK contains the new, innovative, groundbreaking Liquigel capsules to ensure you get the maximum benefit possible! This technology surpasses all other supplement delivery systems, and Olympus Labs is the brand that brought it to you first!
You may ask how this is possible; how can these ingredients have such wide-reaching effects? The secret sauce is in their mechanism of action. Many people may be aware of an ingredient that has been around in the supplement industry for as long as we can remember but never really delivered much. We are talking about Forskolin, a purported Cyclic-Adenosine Monophosphate booster. While it is true that Forskolin is an excellent choice for in-vitro research, such as cell assays, it falls completely short in-vivo (in humans when consumed orally) because it has horrible bioavailability and causes extreme side effects in pretty much everyone.
α-Cedrene and α-Ionone work through a completely different mechanism of action, known as the Olfactory Receptors (ORs). This novel pathway leads to extreme increases in cAMP in the places we want it to occur: muscle and fat cells. Both ingredients are orally bioavailable; research has shown that they build up in the target tissue. What's more, our internal testing led to no gastrointestinal upsets!
But the muscle-building mania doesn't stop there. While cAMP is a potent signalling messenger at the cellular level, which drives robust increases in protein synthesis and fat lipolysis and oxidation, we also included our other superstar ingredients that will potently synergise with elevated cAMP levels to deliver their outstanding effects on an amplified level!
The formula also features other highly effective anabolic agent ingredients, including the truly unique and powerful PhytoFUSE Tectochrysin (5-hydroxy-7-methoxyflavone), which delivers outstanding oral bioavailability and exceptional clinical efficacy of enhancing protein synthesis, skeletal muscle hypertrophy, enhanced ATP production and endurance and recovery as well as arguably the other most significant ingredient breakthrough in recent times with Urolithin-B. This natural ingredient is 80% more anabolic than testosterone and 57% more effective at increasing protein synthesis, helping to increase muscle growth while simultaneously preventing muscle breakdown.
Key Benefits of ALPHABULK
- Multifaceted Targeted Cyclic-Adenosine Monophosphate Booster
- Boost Muscle Protein Synthesis
- mTOR Amplifier
- Boosts Anabolic Signalling
- Supports Lean Muscle Growth
- Supports Leydig Cell Function
- Potent Anti-Catabolic Support
- Supports Strength output
- Enhanced Myogenesis
- Fat oxidation Booster
- Lipolysis enhancer
- Assists with Exercise Performance and Recovery
The Science Behind ALPHABULK
OL introduces an entirely new approach to boosting cAMP in skeletal muscle by targeting a novel pathway known as the ORs. They are predominantly expressed by the main olfactory epithelium at the nasal level and are responsible for the generation of smell; however, according to developing research over recent years, it has been found that they are also found in many different areas of the body, including skeletal muscle, the liver, heart, brain and fat cells and performing some exciting and essential functions.
Before we dive into the individual ingredients in the formula, let’s talk about cAMP, an essential secondary messenger for signal transduction at the cellular level, which has been shown to perform critical functions in regulating skeletal muscle mass and function. This occurs by enhancing the expression of specific target genes, which govern the functions of a series of protein targets, including ion channels, enzymes, and transcription factors. CAMP-elevating agents have been reported to promote significant increases in total protein synthesis and reduce catabolic processes in skeletal muscles.
Increasing levels of cAMP can also support increased levels of lipolysis and oxidation of fatty acids; it is also a key molecule in the regulation of glycogen synthesis and, importantly, the synthesis of critical anabolic hormones such as testosterone through enhancement of Leydig cell function.
α-Cedrene exerts its anabolic effects due to its ability to act as an agonist to the Human OR subtype known as OR10J5, which leads to the activation of a downstream signalling pathway cAMP-protein kinase A-cyclic AMP-responsive element-binding protein (CREB) in the skeletal muscle. This same pathway applies to other areas of the body, such as in the liver and fat cells, whereby improved glucose tolerance, enhanced insulin sensitivity, and enhanced fat lipolysis and oxidation have been noted in research.
Interestingly, α-Ionone exerts potent effects through a different OR subtype known as OR51E2. The downstream effects appear like that of OR10J5, and we can expect the impact detailed above; given it is through a slightly different mechanism of action, we suspect that the combination of the two ingredients will have a 1+1 = 3 effect, leading to far greater elevations in cAMP compared to individually. We fully intend to achieve maximal results, given we have opted for clinical dosages of both ingredients!
Both α-Cedrene and α-Ionone are extremely potent agents, but why stop there? We wanted to drive this formula to new heights and deliver unquestionably powerful effects, so we opted to include additional ingredients that will potently synergise with elevations in cAMP to amplify the product's overall impact.
What better choice than Tectochrysin, an incredibly potent anabolic ingredient in its natural form? Olympus Labs never settles for good; we strive for outstanding. Olympus Labs utilised its custom PhytoFUSE delivery system to help dramatically improve Tectochrysin's bioavailability! Not only does it significantly aid in oral absorption, but it also increases the serum half-life of the compound, allowing a longer duration of action. Typical extracts of Black Ginger Root will only contain minute amounts of Tectochrysin; their extract process yields a highly pure 98% active!
And then there was the ingredient that perfected it all, Urolithin B, which, in studies, outperformed Testosterone while using significantly lower dosages. An ingredient that is essentially a bodybuilder’s dream, a natural ingredient that helps to build lean muscle while preventing muscle breakdown.
With the above in mind, let's dive into more detail on each of the ingredients, outlining how they play their role in the formula:
α-Cedrene: cedarwood oil is an essential oil derived from various types of conifers, such as pine or cypress families. It is a prevalent ingredient used as a cosmetic or food additive. Different active ingredients are found in Cedarwood oil, such as sesquiterpene constituents α-cedrene and β-cedrene, cedrol and thujopsene.
ALPHABULK utilises a very high dose of highly purified, isolated α-cedrene, which exerts unique effects compared to all other actives found in cedarwood.
It has recently been identified as a potent agonist of the OR subtype OR10J5, which, as previously discussed, leads to concentrated increases in cAMP in target tissues such as skeletal muscle and fat cells. Recent research has shown that α-Cedrene is a promising agent that may be applied to enhance the mass and strength of skeletal muscle.
α-Ionone: Ionones are part of the family of compounds known as rose ketones; they are aroma compounds found in small quantities in various essential oils and fruits such as raspberries. Ionones can be found in three forms: alpha, beta and gamma. Due to their intense aroma, they are common ingredients in various fragrances, cosmetics, and food flavouring additives.
ALPHABULK utilises a massive clinical dosage of a highly purified, isolated α-ionone, which serves a very different and, frankly, exciting role. Recent literature has shown that α-ionone is both a potent stimulator of myogenesis and a skeletal muscle anti-atrophic agent.
How do both α-Cedrene and α-Ionone work?
The mechanism through which they exert these potent effects is through boosting cAMP; research suggests that they are both full agonists of OR subtypes OR51E2 and OR10J5, which, when expressed, leads to a substantial increase in cAMP levels and subsequent downstream effects.
Both α-Cedrene and α-Ionone are highly orally bioavailable and build up in various bodily tissues such as skeletal muscle, adipocytes, and the liver, where they can exert their effects where they matter most. They have been shown to affect downstream key anabolic signalling molecules such as PKA Cα, p-CREB, p-FoxO3 and (PGC)-1α1 whilst simultaneously decreasing expression of catabolic signalling molecules such as RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx), which regulate ubiquitin-proteasome-dependent proteolysis. The amount of p-SMAD2/3 (a downstream molecule of myostatin signalling) significantly diminished. In contrast, the amounts of IGF-1 signalling molecules, including p-AKT, p-mTORC, p-S6K1, and p-4E-BP1, increased dramatically in the skeletal muscle of α-ionone-treated subjects. In layperson’s terms, critical anabolic processes are greatly enhanced while simultaneously, key catabolic processes are suppressed, leading to a potent net benefit in promoting anabolism.
Activation of the relevant OR subtypes by both ingredients also positively enhances glucose uptake and increases insulin sensitivity. Research has shown that they lead to reprogramming of metabolic signatures, boosting levels of Adcy3 and genes involved in fatty acid oxidation, with concomitant downregulation of the ability of fat cells to increase levels of fatty acids. Furthermore, cAMP is a vital signalling messenger for the hypothalamic-pituitary-testicular axis and production of essential anabolic hormones such as testosterone; enhanced levels of cAMP directly correlate with enhanced hormone output.
Expect multifaceted benefits from their inclusion, ranging from improved increase in skeletal muscle anabolism, enhanced anabolic hormone production, increased fat lipolysis and oxidation and increased glycogen synthesis.
Tectochrysin PhytoFUSE: Derived from the roots of Black Ginger, this ingredient is essentially a building block that your body uses as a blueprint to create its benefit. A study into the various Methoxy Flavones in Black Ginger showed that Tectochrysin was the most potent of the Methoxy Flavones regarding skeletal muscle hypertrophy, delivering the most significant increases in Myotube diameter. Its beneficial effects include increased protein synthesis and nitrogen retention while promoting other anabolic effects such as increased muscle endurance, muscle recovery, and lean muscle mass through increasing skeletal muscle hypertrophy.
Additionally, Tectochrysin has been shown to aid in skeletal muscle ATP production, lean muscle glucose uptake and exercise performance. PhytoFUSE is a unique delivery technology that enhances the bioavailability and absorption of various compounds, including Methoxy Flavones. Research has shown that this delivery method can substantially improve potency and duration of action,
Urolithin B: One of four metabolites of ellagic acid/ellagitannins. Research has shown supplementing the diet with ellagitannins mitigates muscle damage experienced during intense exercise and protects muscles against stresses induced by a high-fat diet. Clinical research on Urolithin B in mice found that it enhanced myotubes growth and differentiation by increasing protein synthesis. It demonstrated an ability to inhibit the ubiquitin–proteasome pathway (UPP), the principal mechanism for protein catabolism. It also induced muscle hypertrophy and reduced muscle atrophy. Signalling analyses indicate a connection between the androgen receptor and the mTORC1 pathway, possibly via AMPK. In studies, UroB at 15µM promoted androgen receptor activity by 90% vs. testosterone at 100µM, which boosted androgen receptor activity by 50%. Even at significantly lower doses, it outperformed testosterone. Additionally, UroB at 15µM upregulated MPS by 96%, while blood glucose at 100 µM upregulated MPS by just 61%. Once again, at a significantly lower dose, UroB was more effective in increasing muscle protein synthesis.